Saumya Das

A tRNA-derived small RNA orchestrates cardioprotection through distinct cell-type-specific mechanisms

This study identifies a tRNA-derived small RNA that reduces cardiac fibrosis and hypertrophy through cell-type-specific mechanisms in mouse and human cardiac cells.

From Lab to Industry: Awareness of the translational potential of Extracellular Vesicles by the ISEV Translation, Regulation and Advocacy Committee (ISEV-TRA).

The paper surveys awareness of extracellular vesicles' translational potential across academia and industry, highlighting growing interest and spin-out efforts in EV-based products.

State-dependent release of extracellular particles with distinct α2,6-sialylation patterns and small RNA cargo related to neuroinflammation

The paper characterizes microglia-derived extracellular vesicles and non-vesicular particles under inflammatory conditions, showing distinct sialylation patterns and small RNA cargo linked to neuroinflammation.

Exploring Size Exclusion Chromatography Columns 20 and 35 nm Pore Size Effect for Isolation of Extracellular Vesicles

This study compares 20 nm and 35 nm pore size SEC columns for EV isolation, finding that smaller pores improve yield and purity in cell culture media and plasma.

A role of extracellular vesicle-mediated inter-organ communication in obesity-related arrhythmia

This paper shows that obesity-related extracellular vesicles from visceral adipose tissue impair cardiac function and contribute to arrhythmia by affecting cardiomyocytes, fibroblasts, and macrophages.

Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling

This paper develops a conditional-siRNA system that targets calcineurin in cardiac cells to reduce hypertrophy by responding to nppa mRNA, showing specific activation under stress conditions.

The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity

The paper identifies obesity-related transcriptional changes in circulating extracellular vesicles and links them to adipose tissue epigenetics and inflammatory disease risk.

Molecular architecture of human atherosclerosis revealed through integrative human genetics

The paper integrates proteomics and transcriptomics with genetic analyses to identify molecular mechanisms and targets of coronary artery disease.

Isolation and Characterization of Extracellular Vesicles and Non-Vesicular Extracellular Particles from Mouse Tissues

The paper introduces a method to isolate and characterize extracellular vesicles and non-vesicular extracellular particles from mouse tissues for the first time.

Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo

The paper shows neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo, both under pathological and physiological conditions.

Comparison of miRNA profiling methods using synthetic miRNA pools and standardized exRNA samples reveals substantial performance differences

This study compares miRNA profiling methods using synthetic pools and exRNA samples, finding significant differences in reproducibility, accuracy, and sensitivity across platforms.