Quanhu Sheng

The paper performs single-cell transcriptome-wide association analysis to identify cell-type-specific genetic susceptibility genes for colorectal cancer, finding 546 gene-cell-type associations and 347 candidate susceptibility genes.

This study uses spatial transcriptomics to analyze gene expression in heart transplant recipients during rejection, identifying distinct transcriptomic profiles associated with different rejection types and outcomes.

The paper identifies epithelial cell-state transitions linked to disease severity in pediatric eosinophilic esophagitis using single-cell and bulk transcriptomic data.

This study examines how aging and immunosuppression affect immune cell composition and rejection risk in heart transplant recipients, finding lower rejection odds with age and specific transcriptomic changes.

This study integrates single-cell and spatial transcriptomics to identify prognostic fibroblast subpopulations in thyroid cancer progression.

The paper investigates how post-transcriptional modifications on tRNA fragments in HDL affect atherosclerosis by altering immune signaling and macrophage activation.

This study sequenced 35,024 individuals with predominantly African ancestry to address gaps in genomics and healthcare, finding under-documented disease variants and novel associations with drug adverse events and glycemic control.

This paper shows that obesity-related extracellular vesicles from visceral adipose tissue impair cardiac function and contribute to arrhythmia by affecting cardiomyocytes, fibroblasts, and macrophages.

The paper identifies obesity-related transcriptional changes in circulating extracellular vesicles and links them to adipose tissue epigenetics and inflammatory disease risk.

This study shows overnutrition causes hypothyroidism in mice by impairing thyroid hormone biosynthesis and utilization, despite thyroid adaptations, and finds a link between BMI and thyroid vascularization in humans.

The paper integrates proteomics and transcriptomics with genetic analyses to identify molecular mechanisms and targets of coronary artery disease.

The paper identifies ZNF469 as a transcription factor regulating collagen production in liver fibrosis through computational analysis and experimental validation.

This study shows that Tenascin-C enhances Wnt signaling and promotes invasion and metastasis in thyroid cancer through in vitro and in vivo experiments.

The paper uses single-cell RNA-sequencing to identify cell-specific gene expression patterns in high-grade cardiac allograft vasculopathy, finding increased CD4+ T central memory cells and monocytes, and 745 differentially expressed genes.

This study examines cytokine and chemokine receptor expression in adipose tissue endothelial cells of HIV-positive individuals, identifying receptor differences and their potential role in vascular dysfunction.

This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.

The paper investigates how HDL binds to single-stranded small RNAs through interactions with apoA-I, revealing mechanisms that may enable extracellular RNA communication.

This study shows that inhibiting miR-22-3p reduces lymphocyte accumulation and kidney disease in a mouse model of systemic lupus erythematosus.

This paper introduces sc-UniFrac, a framework to quantify compositional diversity in cell populations across single-cell transcriptome datasets, demonstrating its utility in various applications.

The paper introduces TIGER, a pipeline for analyzing extracellular small RNAs, demonstrating its ability to identify sRNAs on lipoproteins and in biofluids with high accuracy.