4R-Tobacco-Cembranoid is a Positive Allosteric Modulator of the Alpha7 Nicotinic Acetylcholine Receptor that modulates inflammation-induced thermal hypersensitivity in mice
Luis G. Rivera-García, Adela M. Francis-Malavé, Torri D. Wilson, Pedro A. Ferchmin, Vesna A. Eterović, Yarimar Carrasquillo
This study identifies 4R-Tobacco-Cembranoid as a positive allosteric modulator of 7nAChRs that reduces thermal hypersensitivity and inflammation in mice, with sex-specific effects.
bioRxiv · Jan 22, 2022 · PreprintNeuroscience