When lipids embrace RNA: pH-driven dynamics and mechanisms of LNP-mediated siRNA delivery
Kazi Amirul Hossain, Mariana Valério, Pedro Medina, Paulo C. T. Souza, Modesto Orozco
This study uses simulations to analyze LNP-mediated siRNA delivery, revealing pH-dependent structural changes and a mechanism for endosomal escape involving RNA-lipid interactions.
bioRxiv · Feb 12, 2026 · PreprintBiophysics