Author

Kazi Amirul Hossain

Institute for Research in BiomedicineORCID 0000-0002-1149-964XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mixed model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Modesto OrozcoiD· 3 shared Adrián Martínez-JiméneziD· 1 shared Borja Ochoa-LizarraldeiD· 1 shared Carol V. RobinsoniD· 1 shared Ekaitz Errasti‐MurugarreniD· 1 shared Giulia PalermoiD· 1 shared Guillem Pont-EspinósiD· 1 shared Haigang SongiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

Modesto OrozcoORCID

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3 papers

Recent·Most cited

Structural basis of selective phospholipid recognition and local membrane deformation by CTL1

Hanxing Jiang, Adrián Martínez-Jiménez, Kazi Amirul Hossain, Haigang Song, Borja Ochoa-Lizarralde, Jorge Pedro López-Alonso, Guillem Pont-Espinós, Raúl Estévez, Modesto Orozco, Carol V. Robinson, Iban Ubarretxena‐Belandia, Igor Tascón, Ekaitz Errasti‐Murugarren

This study identifies CTL1 as a phospholipid-binding protein that deforms membranes, revealing its structural basis and potential role in phospholipid homeostasis.

bioRxiv · Oct 3, 2026 · PreprintBiophysics

When lipids embrace RNA: pH-driven dynamics and mechanisms of LNP-mediated siRNA delivery

Kazi Amirul Hossain, Mariana Valério, Pedro Medina, Paulo C. T. Souza, Modesto Orozco

This study uses simulations to analyze LNP-mediated siRNA delivery, revealing pH-dependent structural changes and a mechanism for endosomal escape involving RNA-lipid interactions.

bioRxiv · Feb 12, 2026 · PreprintBiophysics

Flexibility in PAM Recognition Expands DNA Targeting in xCas9

Kazi Amirul Hossain, Łukasz Nierzwicki, Modesto Orozco, Jacek Czub, Giulia Palermo

This study investigates how xCas9 expands DNA targeting by recognizing alternative PAM sequences through increased flexibility in its PAM-interacting region.

eLife · Feb 10, 2025Peer-reviewedBiophysics