Differential DNA modification of an enhancer at the IGF2 locus affects dopamine synthesis in patients with major psychosis
Shraddha Pai, Peipei Li, Bryan A. Killinger, Lee L. Marshall, Peixin Jia, Ji Liao, Artūras Petronis, Piroska E. Szabó, Viviane Labrie
The paper identifies reduced DNA modifications at an IGF2 enhancer in psychosis patients, linking it to disrupted dopamine synthesis in mice.
bioRxiv · Apr 6, 2018 · PreprintNeuroscience