Lee L. Marshall

This study performs a transcriptome-wide alternative splicing analysis in bipolar disorder, identifying complex splicing events and candidate genes associated with the disorder.

The paper shows that Anillin-dependent actin assembly at PML NBs protects genome stability by shielding under-replicated DNA across cell cycles.

The paper identifies mesendoderm progenitor cells in mouse embryos and shows their contribution to endoderm and mesoderm lineages through lineage tracing and analysis of Mixl1 function.

The paper shows that early life environmental exposures in male mice lead to neurodevelopmental behaviors and molecular changes, while females are unaffected.

This study uses RNA sequencing in multiplex bipolar disorder families to identify differentially expressed genes and pathways, finding significant lncRNAs and ion homeostasis dysregulation.

The paper identifies that Tet2 loss promotes ciliogenesis and reduces α-synuclein pathology in Parkinson's disease models.

This study identifies up-regulation of human endogenous retrovirus (HERV) transcripts in Parkinson's disease (PD) across multiple tissues and blood, linking TE activation to PD pathogenesis and potential treatment monitoring.

This paper develops a method to label, extract, and purify Lewy pathology from formalin-fixed human tissue using biotinylation by antigen recognition, revealing molecular signatures associated with Parkinson's and Dementia with Lewy Bodies.

The paper identifies increased TET2 expression as a driver of epigenetic dysregulation in Parkinson’s disease neurons and shows that reducing Tet2 activity is neuroprotective in mice.

This study identifies epigenetic differences in hemispheric asymmetry in healthy brains, Parkinson’s disease, and aging, showing increased asymmetry in PD and its association with disease progression.

The paper identifies reduced DNA modifications at an IGF2 enhancer in psychosis patients, linking it to disrupted dopamine synthesis in mice.