Bryan A. Killinger

Seed Amplification Assay-Based Detection of Alpha-Synuclein Aggregates Outperforms Immunohistochemical Analysis in the Intestinal Mucosal Biopsies of Parkinson's Disease and Multiple System Atrophy Participants

This study compares a seed amplification assay for alpha-synuclein aggregates with immunohistochemistry in intestinal biopsies of Parkinson's disease and multiple system atrophy patients, finding the assay detects aggregates more frequently and with higher specificity.

Proximity labeling reveals unique and shared interactomes of unmodified and pyroglutamate amyloid beta in human hippocampus in Alzheimers disease

This study uses proximity labeling to compare the interactomes of pyroglutamate-modified and unmodified amyloid beta in AD and control hippocampus, identifying unique and shared protein interactions.

α-Synuclein Seeding in Dopaminergic Neurons Transplanted into the Putamen of Parkinson's Disease Patients

The paper investigates whether α-synuclein seeding from host tissue contributes to Lewy pathology in dopaminergic neuron grafts in Parkinson's disease patients.

Preformed Fibril Seeding Reshapes the Phosphorylated α-Synuclein Proximal Proteome in the Olfactory Bulb

Proximity proteomics in PFF-seeded mouse olfactory bulb shows aggregated phospho-S129 alpha-synuclein mostly reprioritizes existing interactions toward axon-glia, myelin and proteostasis proteins, with a conserved 107-protein signature.

Aggregation-prone alpha-synuclein proteoforms and dysregulated molecular signatures in the vermiform appendix of synucleinopathy patients

The paper examines alpha-synuclein aggregation and molecular changes in appendix tissues from synucleinopathy patients compared to controls.

CD11b Activation Reduces Myeloid Brain Infiltration and Mitigates Synucleinopathy in a Model of Parkinson's Disease

This study shows that CD11b agonism with LA1 reduces microglial activation and myeloid cell infiltration, thereby mitigating synucleinopathy in a Parkinson's disease model.

Physiological alpha-synuclein S129 phosphorylation mediates postsynaptic and nuclear interactions in the human brain

The paper maps physiological alpha-synuclein S129 phosphorylation interactomes in the human brain and confirms their presence in healthy non-human primates.

Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinsons disease reveals unique and shared pathological features.

This study compares alpha-synuclein-interactomes in multiple system atrophy and Parkinson's disease to identify unique and shared pathological features.

Alpha-synuclein aggregates are phosphatase resistant

This study shows that alpha-synuclein aggregates are resistant to phosphatase dephosphorylation and introduces a method using calf intestinal phosphatase (CIAP) to specifically detect aggregated PSER129 in biological samples.

Neither alpha-synuclein-preformed fibrils derived from patients with GBA1 mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb.

The study tests whether GBA1 mutations or mouse genotype affect alpha-synuclein seeding in mice, finding no significant influence on seeding efficacy or pathology spread.

Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis

The paper identifies PSER129 accumulation in healthy olfactory bulb mitral cells and links it to synucleinopathy pathogenesis through protein interactome analysis.

Detection And Purification Of Lewy Pathology From Formalin Fixed Primary Human Tissue Using Biotinylation By Antigen Recognition

This paper develops a method to label, extract, and purify Lewy pathology from formalin-fixed human tissue using biotinylation by antigen recognition, revealing molecular signatures associated with Parkinson's and Dementia with Lewy Bodies.

Gut microbiome dysbiosis is associated with elevated toxic bile acids in Parkinson's disease

This study identifies elevated toxic bile acids in Parkinson's disease patients and links them to gut microbiome dysbiosis and early biliary changes.

Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

The paper identifies increased TET2 expression as a driver of epigenetic dysregulation in Parkinson’s disease neurons and shows that reducing Tet2 activity is neuroprotective in mice.

Differential DNA modification of an enhancer at the IGF2 locus affects dopamine synthesis in patients with major psychosis

The paper identifies reduced DNA modifications at an IGF2 enhancer in psychosis patients, linking it to disrupted dopamine synthesis in mice.