Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signaling
Yan Sun, Vasanth Chanrasekhar, Chase W. Kessinger, Peiyang Tang, Yunan Gao, Sarah Kamli-Salino, Katherine Nelson, Mirela Delibegović, E. Dale Abel, Maria Irene Kontaridis
This study shows that deleting PTP1B in cardiomyocytes protects against high-fat diet-induced heart disease by promoting fatty acid metabolism and reducing glucose metabolism through a novel PTP1B/PKM2/AMPK axis.
bioRxiv · May 19, 2023 · PreprintMolecular Biology