Yan Sun

Early blood-spinal cord barrier stabilization preserves peri-lesional tissue and improves recovery after SCI

This study identifies early vascular leakage beyond the injury epicenter as a driver of secondary pathology after SCI and shows that stabilizing the blood-spinal cord barrier improves recovery.

Rigosertib reverses hypertrophic cardiomyopathy in RAF1-associated Noonan syndrome

This paper shows rigosertib reverses hypertrophic cardiomyopathy in RAF1-associated Noonan syndrome using Drosophila, iPSC, and mouse models.

Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signaling

This study shows that deleting PTP1B in cardiomyocytes protects against high-fat diet-induced heart disease by promoting fatty acid metabolism and reducing glucose metabolism through a novel PTP1B/PKM2/AMPK axis.