Molecular basis of the urate transporter URAT1 inhibition by gout drugs
Yang Suo, Justin G. Fedor, Han Zhang, Kalina Tsolova, Xiaoyu Shi, Kedar Sharma, Shweta Kumari, Mario Juan Borgnia, Peng Zhan, Wonpil Im, Seok‐Yong Lee
This study determines the cryo-EM structures of URAT1 with inhibitors and reveals their binding mechanisms and conformational changes.
Nature Communications · Jun 4, 2025Peer-reviewedBiophysics