Author

Seok‐Yong Lee

Duke UniversityORCID 0000-0002-0662-9921Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Justin G. FedoriD· 2 shared Mario Juan BorgniaiD· 2 shared Cheon-Gyu ParkiD· 1 shared Han ZhangiD· 1 shared Hyuk-Joon LeeiD· 1 shared Kalina Tsolova· 1 shared Kedar SharmaiD· 1 shared Peng Zhan· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Justin G. FedorORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 9, 2025

Structural Basis of Cold and Menthol Sensing by TRPM8

Hyuk-Joon Lee, Cheon-Gyu Park, Justin G. Fedor…·Seok‐Yong Lee

This study presents cryo-EM structures and functional analyses of TRPM8 activation by cold and menthol, revealing mechanisms of cold sensing and menthol specificity.

5 citations

humancryo-EM

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedJun 4, 2025

Molecular basis of the urate transporter URAT1 inhibition by gout drugs

Yang Suo, Justin G. Fedor, Han Zhang…·Seok‐Yong Lee

This study determines the cryo-EM structures of URAT1 with inhibitors and reveals their binding mechanisms and conformational changes.

30 citationstop 1%

humancryo-EM

𝕏 PostBluesky