CHPT1-LCAT rewires lipolysis towards ferroptosis
Lingdi Ma, Pengfei Teng, Qian Zhang, Qinchi Liu, Jingjing Lu, Haoyue Wang, Yang Zhang, Zihao Guo, Ronghui Yang, Luxin Qiao, Lifang Li, Yanxia Fu, Bo Li
This study identifies DAG as a licensing lipid intermediate for ferroptosis, revealing a novel CHPT1-iLCAT axis that routes DAG to promote ferroptosis and suppress tumor growth.
bioRxiv · Mar 16, 2026 · PreprintCell Biology