Post-Inhibitory Rebound by δ-Cells Transforms Inhibition into Excitationand Redefines Islet Plasticity.
Alejandro Tamayo, Dayleen Hakim Rodriguez, Elisabeth Pereira, Sergio Camacho-Becerra, Luciana Mateus Gonçalves, Per-Olof Bergreen, Madina Sokolov, Rafael Arrojo e Drigo, Oscar Alcazar, Rayner Rodriguez‐Diaz
This paper identifies post-inhibitory rebound (PIR) in pancreatic islets as a mechanism converting δ-cell inhibition into excitation, revealing dynamic paracrine signaling rather than static inhibition.
bioRxiv · Nov 10, 2025 · PreprintPhysiology