Rafael Arrojo e Drigo

This study shows that MAFA promotes pancreatic islet maturation by enhancing cell growth, metabolic function, and stress resilience in stem cell-derived islets.

This study uses MIMS-EM to analyze metabolic turnover in C. elegans during dietary restriction, revealing tissue- and resource-specific changes at multiple scales.

QuantEM provides a vision transformer-based platform for EM data segmentation and analysis, achieving accurate zero-shot segmentation with less data than existing models.

The paper maps 3D genome organization and DNA methylation across 86,689 single nuclei from 16 human tissues, revealing cell-type-specific variations and discrepancies between methylation and chromatin structure.

This study investigates how calorie restriction modulates beta cell Ca2+ homeostasis and network connectivity, finding that CR beta cells exhibit faster, shorter Ca2+ oscillations and reduced network connectivity.

This study shows calorie restriction delays type 1 diabetes onset in NOD mice by enhancing glucose homeostasis and promoting a pro-tolerogenic islet microenvironment through increased PD-L1 expression.

This paper identifies post-inhibitory rebound (PIR) in pancreatic islets as a mechanism converting δ-cell inhibition into excitation, revealing dynamic paracrine signaling rather than static inhibition.

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.

This study shows overnutrition causes hypothyroidism in mice by impairing thyroid hormone biosynthesis and utilization, despite thyroid adaptations, and finds a link between BMI and thyroid vascularization in humans.

This study investigates islet cell dysfunction in type 1 diabetes by integrating electrophysiological, transcriptomic, and machine learning analyses of human islet cells from T1D donors.

This study shows that ER-phagy drives age-related ER remodeling and lifespan, revealing it as a protective mechanism in aging.