Proximal Tubule-on-Chip for Predicting Cation Transport: Dynamic Insights into Drug Transporter Expression and Function
Isy Petit, Quentin Faucher, Jean-Sébastien Bernard, Perrine Giunchi, Antoine Humeau, François‐Ludovic Sauvage, Pierre Marquet, Nicolas Védrenne, Florent Di Meo
This study develops a proximal tubule-on-chip model to investigate dynamic drug transporter expression and function, showing flow exposure modulates mRNA expression and enhances cell polarization.
Scientific Reports · Jan 20, 2025Peer-reviewedPharmacology & Toxicology