Peter D Keightley

Global population divergence and admixture of the brown rat (Rattus norvegicus)

This study uses SNP data to infer the global phylogeography of brown rats, revealing 13 evolutionary clusters and tracing their expansion routes linked to human trade and urban environments.

Fitness effects of new mutations in Chlamydomonas reinhardtii across two stress gradients

The paper examines how mutations affect fitness in Chlamydomonas reinhardtii under different stress conditions and finds that mutational effects are stress-specific and depend on genetic background.

Direct estimate of the spontaneous mutation rate uncovers the effects of drift and recombination in the Chlamydomonas reinhardtii plastid genome

The paper directly estimates the mutation rate in the plastid genome of Chlamydomonas reinhardtii and shows it experiences stronger genetic drift and linkage disequilibrium compared to the nuclear genome.

Recent evolution in Rattus norvegicus is shaped by declining effective population size

This study analyzes genome sequences of brown rats to show recent population size decline and its impact on genetic diversity and mutation patterns.

Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii

This study identifies extensive de novo mutation rate variation in Chlamydomonas reinhardtii through genome sequencing of mutation accumulation lines, revealing strain-specific and sequence-context-dependent mutability.