A TLR2-associated entry pathway promotes productive dengue virus serotype 2 infection and inflammatory responses in classical monocytes
Jorge Andrés Castillo, Madhura Punekar, Vinit Upasani, Peter Duinkerken, Bram M. ter Ellen, Heidi H. van der Ende-Metselaar, Silvio Urcuqui Inchima, Jolanda M. Smit, Izabela A. Rodenhuis‐Zybert
This study shows that TLR2 promotes DENV2 infection and inflammation in classical monocytes, with subset-specific effects and implications for endothelial barrier disruption.
bioRxiv · Oct 2, 2026 · PreprintMicrobiology