AI-derived Protein Structures Validation: AlphaFold2 Models in the Twilight Zone
Peter Griffin, Giuseppe Deganutti, Kamiya Jadeja, Camila Idigbe, Ludovico Pipitò, Lorena Mejuto, Choa Ping Ng, Saffron Peck, Jennifer Greaves, Christopher Arthur Reynolds
The paper validates AlphaFold2-generated protein structures by aligning them with structurally similar proteins, showing success for challenging cases like ABHD16A.
bioRxiv · May 12, 2026 · PreprintBioinformatics