Christopher Arthur Reynolds

The paper identifies ABHD13 and ABHD16A as deacylases regulating SNAP25 family proteins and maps substrate selectivity to a single amino acid position.

The paper validates AlphaFold2-generated protein structures by aligning them with structurally similar proteins, showing success for challenging cases like ABHD16A.

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

This paper introduces mwSuMD, a molecular dynamics algorithm, to simulate complex structural transitions in GPCRs without energy bias, demonstrating its application in studying receptor activation and GDP release.

This study computationally evaluates the druggability of the SARS-CoV-2 spike protein stalk using molecular docking and dynamics simulations, finding it challenging due to structural flexibility.

This study uses molecular dynamics simulations to investigate how heparinoids interact with the SARS-CoV-2 spike protein and ACE2 receptor, revealing mechanisms behind their inhibitory effects.

This study performs a GWAS on random glucose measurements in 493,036 individuals, identifying 128 loci associated with glycaemic traits and providing insights into diabetes biology and treatment.