Precise and programmable C:G to G:C base editing in genomic DNA
Liwei Chen, Jung Eun Park, Peter Paa, Priscilla D. Rajakumar, Yi Ting Chew, Swathi N. Manivannan, Wei Leong Chew
This paper develops C:G to G:C base editors to correct specific SNPs in human cells, achieving up to 37% editing efficiency and 90% specificity.
bioRxiv · Jul 21, 2020 · PreprintSynthetic Biology