Isolectin B4 (IB4)-conjugated streptavidin for the selective knockdown of proteins in IB4-positive (+) nociceptors
Oliver Bogen, Dionéia Araldi, Anatol Sucher, Kord M. Kober, Peter T. Ohara, Jon D. Levine
This paper demonstrates that IB4-conjugated streptavidin can selectively knock down PKCε in IB4+ nociceptors, reversing hyperalgesic priming in a chronic pain model.
Molecular Pain · Jan 1, 2024Peer-reviewedNeuroscience