A role for RNA and DNA:RNA hybrids in the modulation of DNA repair by homologous recombination
Giuseppina D’Alessandro, Marek Adamowicz, Donna Whelan, Sean Michael Howard, Corey Winston Jones-Weinert, Valentina Matti, Eli Rothenberg, Petr Cejka, Fabrizio d’Adda di Fagagna
The paper shows dilncRNAs form DNA:RNA hybrids at DSBs, which are recognized by BRCA1 and promote HR repair, with BRCA2 regulating hybrid levels via RNase H2.
bioRxiv · Jan 29, 2018 · PreprintCell Biology