Author

Marek Adamowicz

The Francis Crick Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:DNA methylation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

Amit GautamiD· 1 shared Annie Albert Demin· 1 shared Aurora Irene IdilliiD· 1 shared Benura Azeroglu· 1 shared Corey Winston Jones-Weinert· 1 shared Donna Whelan· 1 shared Eli Rothenberg· 1 shared Fabrizio d’Adda di Fagagna· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperMolecular Biology

Amit GautamORCID

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Author profile →

3 papers

Recent·Most cited

DNA Polymerase beta Accelerates Cellular DNA Base Excision Repair by Suppressing Excessive PARP1 Engagement

Annie Albert Demin, Marek Adamowicz, Jan Bražina, Amit Gautam, Keith W. Caldecott

This study shows that DNA polymerase beta suppresses excessive PARP1 engagement during DNA base excision repair, enabling efficient repair and preventing transcriptional suppression.

bioRxiv · Jul 21, 2026 · PreprintMolecular Biology

Distinct ATRX functions cooperate with 9-1-1 and CST complexesto safeguard replication and telomere integrity

Sandra Segura‐Bayona, Marija Maric, Tohru Takaki, Zornitsa Manova, Tyler H. Stanage, Aurora Irene Idilli, Graeme Hewitt, Feras E. Machour, Rhona Millar, Marek Adamowicz, Ronnie Ren Jie Low, Phil Ruis, Benura Azeroglu, Todd Fallesen, Harshil Patel, , Simon J. Boulton

This study identifies distinct roles of ATRX in safeguarding genome and telomere integrity through interactions with CST and 9-1-1 complexes, revealing context-dependent mechanisms.

Nature Structural & Molecular Biology · Jun 30, 2026Peer-reviewedMolecular Biology

A role for RNA and DNA:RNA hybrids in the modulation of DNA repair by homologous recombination

Giuseppina D’Alessandro, Marek Adamowicz, Donna Whelan, Sean Michael Howard, Corey Winston Jones-Weinert, Valentina Matti, Eli Rothenberg, Petr Cejka, Fabrizio d’Adda di Fagagna

The paper shows dilncRNAs form DNA:RNA hybrids at DSBs, which are recognized by BRCA1 and promote HR repair, with BRCA2 regulating hybrid levels via RNase H2.

bioRxiv · Jan 29, 2018 · PreprintCell Biology