ESBL plasmid compatibility with the surrounding microbial community influences ESBL gene survival under CRISPR-antimicrobial targeting
Cindy Given, Ilmur Jonsdottir, Krista Norvasuo, Petra Paananen, Pilvi Ruotsalainen, Teppo Hiltunen, Marianne Gunell, Antti Hakanen, Matti Jalasvuori, Reetta K. Penttinen
This study shows CRICON reduces ESBL prevalence in bacterial communities, but ESBL persistence depends on initial community composition and plasmid escape into competitive hosts.
bioRxiv · Apr 15, 2025 · PreprintMicrobiology