The constitutive oncogenic and signaling activities of phospha-tidylinositol 3-kinase (PI3K) isoforms p110β and p110δ
Yoshihiro Ito, Petra Pavlickova, Claire S. Levy, Sohye Kang, Jonathan Ross Hart, Lynn A. Ueno, Peter K. Vogt
This study identifies the PXXP motif in the ABD of p110β and p110δ as essential for their enhanced oncogenic and signaling activities compared to p110.
bioRxiv · Jun 26, 2025 · PreprintCancer Biology