The pyriproxyfen metabolite 4’OH- pyriproxyfen disrupts thyroid hormone signaling and enhances Musashi-1 levels in neuroprogenitors
Petra Spirhanzlova, Sebastien Le Mevel, Karn Wejaphikul, Bilal Mughal, Jean-David Gothie, Anthony Sebillot, Lucille Butruille, Michelle Leemans, Theo Visser, Sylvie Remaud, Jean-Baptiste Fini, Barbara Demeneix
This paper shows that the pyriproxyfen metabolite 4’OH-pyriproxyfen disrupts thyroid hormone signaling and increases Musashi-1 levels in neuroprogenitors, potentially enhancing Zika virus replication.
bioRxiv · Jun 27, 2018 · PreprintPharmacology & Toxicology