Virtual phenotypic screening discovers novel scaffolds inhibiting the PI3K/mTOR pathway
Alexander P. Wu, Heming Yao, Burkhard Höckendorf, Garrett Gaskins, Nont Kosaisawe, Ziqing Lu, Phil Hanslovsky, Oleg Mayba, Nicholas J. Skelton, Gabriele Scalia, John G. Moffat, Tommaso Biancalani, Jan-Christian Hütter, David Richmond
The paper introduces PhenoCompass, a model for virtual phenotypic screening that identifies novel PI3K/mTOR inhibitors from a large compound library.
bioRxiv · Jun 14, 2026 · PreprintBioinformatics