Burkhard Höckendorf

The paper introduces PhenoCompass, a model for virtual phenotypic screening that identifies novel PI3K/mTOR inhibitors from a large compound library.

This study shows that BRD4 recruitment can desilence transcription within repressive chromatin without removing H3K9me3 or HP1, challenging conventional models of chromatin regulation.

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.

The paper introduces a contrastive analysis framework to disentangle perturbation effects from natural cell variation in optical pooled screens, showing improved performance in generating embeddings and reducing technical artifacts.

The paper shows retinal stem cells in fish coordinate post-embryonic eye growth by modulating cell division parameters between neural retina and retinal pigmented epithelium.