An area postrema GLP-1R to NTS pathway dissociates semaglutide-induced satiation, nausea and reduced food motivation from satiety
Lauren Jones, Ella Cross, Yuqi Song, Nicholas Monaco, Phoebe Claxton, Yu Yuan, Stefan Trapp, Alice E. Adriaenssens, Daniel I. Brierley
This study identifies distinct neural circuits in the brainstem mediating semaglutide's effects on satiation, nausea, and food motivation, showing they are dissociable and involve GLP-1R and non-GLP-1R neurons.
bioRxiv · Aug 19, 2026 · PreprintNeuroscience