Stefan Trapp

This study identifies distinct neural circuits in the brainstem mediating semaglutide's effects on satiation, nausea, and food motivation, showing they are dissociable and involve GLP-1R and non-GLP-1R neurons.

The paper identifies opposing roles of GIPR neurons in the area postrema and nucleus tractus solitarius in controlling feeding behavior and satiation.

This study shows that chronic activation of GLP-1 neurons in the brainstem reduces food intake and causes sustained weight loss in obese mice.

This study identifies brainstem GLP-1 neurons as essential for lorcaserin's effect on reducing food intake in mice and suggests combination therapy with GLP-1R agonists may enhance efficacy.

The paper shows that central and peripheral GLP-1 systems independently suppress eating, and PPGNTS neuron activation addsitively enhances this effect with GLP-1 agonists.