MSH2 knock-down shows CTG repeat stability and concomitant upstream demethylation at the DMPK locus in myotonic dystrophy type 1 human embryonic stem cells
Silvie Franck, Lise Barbé, Simon Ardui, Yannick De Vlaeminck, Joke Allemeersch, Dominika Dziedzicka, Claudia Spits, Fien Vanroye, Pierre Hilven, Geoffrey Duqué, Joris Robert Vermeesch, Alexander Gheldof, Karen Sermon
This study shows that MSH2 knock-down stabilizes CTG repeats and reduces upstream CpG methylation in DM1 hESCs, suggesting a link between DNA repair and epigenetic changes in DM1.
Human Molecular Genetics · Nov 1, 2020Peer-reviewedGenetics