Investigating the p21 Ubiquitin-Independent Degron Reveals a Dual Degron Module Regulating p21 Degradation and Function.
Marianna Riutin, Pnina Erez, Julia Adler, Assaf Biran, Nadav Myers, Yosef Shaul
This study identifies the p21 RRLIF box as a ubiquitin-independent degron that interacts with the PSMA3 Trapper, regulating p21 degradation and senescence in response to DNA damage.
Cells · Oct 9, 2024Peer-reviewedMolecular Biology