Assaf Biran

The paper shows that ligand discrimination can occur at the population level through response heterogeneity in dimeric and heterodimeric receptor systems.

This study identifies the p21 RRLIF box as a ubiquitin-independent degron that interacts with the PSMA3 Trapper, regulating p21 degradation and senescence in response to DNA damage.

The paper identifies PSMA3 as a receptor for 20S proteasome-mediated degradation of intrinsically disordered proteins (IDPs) and shows its C-terminal fragment inhibits IDP degradation.