Yosef Shaul

IKKα and IKKβ serve as kinase-independent scaffolds that prevent proteasomal degradation of NEMO

This study shows that IKKα and IKKβ stabilize NEMO via kinase-independent scaffolding, preventing its proteasomal degradation and NF-κB signaling.

Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Model of Amyloidosis

This study shows that disrupting the brain-spleen axis accelerates disease progression in amyloidosis by impairing monocyte-microglia communication.

Genetic Information Processing Complexity as a Determinant of Virus Diversity

The paper quantifies viral genome expression and replication complexity using a propagation index and finds it correlates with viral diversification across multiple taxonomic levels.

Proteasome Caspase-Like Activity Regulates Stress Granules and Proteasome Condensates

This study shows that proteasome caspase-like activity is essential for stress granule formation and regulates proteasome condensates under stress.

c-Abl Phosphorylates Plk1 in Facilitating DNA Damage-Induced G2/M Checkpoint Release with a Trade-off of Micronuclei Formation

This study shows c-Abl phosphorylates Plk1 to facilitate G2/M checkpoint release, but this process increases micronuclei formation, revealing a trade-off in DDR termination.

Investigating the p21 Ubiquitin-Independent Degron Reveals a Dual Degron Module Regulating p21 Degradation and Function.

This study identifies the p21 RRLIF box as a ubiquitin-independent degron that interacts with the PSMA3 Trapper, regulating p21 degradation and senescence in response to DNA damage.

Recruitment of the protein phosphatase-1 catalytic subunit to promoters by the dual-function transcription factor RFX1

This study identifies a mechanism by which RFX1 regulates target genes through its interaction with PP1c, recruiting the phosphatase to promoters to modulate transcription factors and RNA Polymerase II.

A short HBV RNA region induces RNR-R2 expression in non-cycling cells and in primary human hepatocytes

The paper identifies a 125-base RNA region in HBV transcripts that induces RNR-R2 expression in non-cycling cells and primary human hepatocytes without requiring HBx protein.

A 20S proteasome receptor for degradation of intrinsically disordered proteins

The paper identifies PSMA3 as a receptor for 20S proteasome-mediated degradation of intrinsically disordered proteins (IDPs) and shows its C-terminal fragment inhibits IDP degradation.