Highly specific mRNA cleavage by the MazF endoribonuclease orchestrates stationary transcriptome remodeling and rapid regrowth in Gram-positive bacteria
Regev Frenkel, Shira Omer Bendori, Tom Borenstein, Bar Tenennbaum, Shani Shalev, Nadejda Sigal, Y C Li, Polina Guler, Avigail Zarzar, José R. Penadés, Avigdor Eldar
This study shows that MazF toxin in Gram-positive bacteria specifically cleaves mRNAs to regulate stress response and enable rapid regrowth.
bioRxiv · Aug 6, 2026 · PreprintMicrobiology