Cancer BiologybioRxivPreprint
Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
Pooneh Koochaki, Biao Qiu, Jesse A. Coker…·Abhishek A. Chakraborty
This study determines the cryo-EM structure of SLC1A1 bound to an inhibitor, identifies its binding mechanism, and develops improved inhibitors with enhanced cytotoxicity in kidney cancer cells.
DOI 10.1101/2025.07.03.663021