Guide RNA truncation as a tunable approach for modulating base editing outcomes
Anila George, K. Manjunatha Prasad, Poornasree Sadanandan, Srujan Kumar Marepally, Saravanabhavan Thangavel, Kumarasamypet Murugesan Mohankumar
This study shows that truncating guide RNAs can modulate base editing outcomes by reducing bystander editing while preserving on-target conversion in multiple contexts.
bioRxiv · Sep 13, 2026 · PreprintBioengineering