Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis
Charles H. Earnshaw, Poppy Dunn, Shih‐Chieh Chiang, Agrin Moeini, Maria A. Koufaki, Eduardo Bonavita, Massimo Russo, Laëtitia Nebot-Bral, Kimberley Hockenhull, Erin Richardson, Anna Pidoux, Charlotte R. Bell, Alexander R. Baker, Richard Reeves, Robert Sellers, , Santiago Zelenay
This study shows glucocorticoids enhance anti-tumor immunity by inhibiting the GARP/TGF-β axis in melanoma, improving prognosis and response to immunotherapy.
bioRxiv · Jul 24, 2025 · PreprintCancer Biology