Author

Robert Sellers

Cancer Research UK Manchester InstituteORCID 0000-0002-8193-9356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Sudhakar SahooiD· 4 shared Alexander R. BakeriD· 2 shared Caroline DiveiD· 2 shared David C. WedgeiD· 2 shared Robert Glen BristowiD· 2 shared Agrin MoeiniiD· 1 shared Ali Al-Anbaki· 1 shared Amen ShamimiD· 1 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCancer Biology

Sudhakar SahooORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Proteomics-constrained deconvolution reveals spatial cell-type programs in tumours

Esra Büşra Işık, Michael Haley, Ali Al-Anbaki, Leoma D. Bere, Federico Roncaroli, Karen Piper Hanley, Kevin N. Couper, David C. Wedge, Robert Sellers, Alexander R. Baker, Pedro Oliveira, Jack Ashton, Robert Glen Bristow, Mauricio A. Álvarez, Sokratia Georgaka, Magnus Rattray

PISTACHIO improves spatial cell-type deconvolution in tumours using proteomics constraints and non-negative matrix factorization.

bioRxiv · Jun 22, 2026 · PreprintBioinformatics

Whole-genome pre-amplification as a viable approach for genomic screening of FFPE-derived DNA samples

Conrado Guerrero Quiles, Taha Lodhi, Robert Sellers, Sudhakar Sahoo, John Weightman, Wolfgang Breitwieser, Diego Sánchez Martinez, Matej Bartak, Amen Shamim, Steve Lyons, Kimberley Jayne Reeves, Rachel Reed, Peter Hoskin, Catharine West, Laura J. Forker, , Luisa Vanesa Biolatti

This study evaluates DLMDA for improving DNA yield from FFPE samples but finds it reduces CNA sensitivity.

bioRxiv · Mar 29, 2026 · PreprintMolecular Biology

Epigenetic silencing of transposable elements by IRF2BP2 is a selective dependency of myeloid leukemia

Jingru Xu, Jessica Whittle, Liam Clayfield, Michael Lie‐A‐Ling, Eve Leddy, Duncan L. Smith, Robert Sellers, Özgen Deniz, Georges Lacaud

This study identifies IRF2BP2 as a critical regulator of transposable element silencing in AML, showing its loss leads to TE activation and leukemia cell death.

bioRxiv · Nov 12, 2025 · PreprintCancer Biology

Studying a human genetic model of lung squamous cell carcinoma with organotypic cultures and xenografts uncovers distinct advantages of each system and implicates NOTCH1 loss in tumour development

Julia Ogden, Robert Sellers, Anthony Oojageer, Sudhakar Sahoo, Caroline Dive, Carlos Lopez-Garcia

The paper compares organotypic cultures and xenografts of a human lung squamous cell carcinoma model, finding that xenografts better reflect tumor gene expression and reveal NOTCH1 loss as a driver.

bioRxiv · Aug 28, 2025 · PreprintCancer Biology

Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis

Charles H. Earnshaw, Poppy Dunn, Shih‐Chieh Chiang, Agrin Moeini, Maria A. Koufaki, Eduardo Bonavita, Massimo Russo, Laëtitia Nebot-Bral, Kimberley Hockenhull, Erin Richardson, Anna Pidoux, Charlotte R. Bell, Alexander R. Baker, Richard Reeves, Robert Sellers, , Santiago Zelenay

This study shows glucocorticoids enhance anti-tumor immunity by inhibiting the GARP/TGF-β axis in melanoma, improving prognosis and response to immunotherapy.

bioRxiv · Jul 24, 2025 · PreprintCancer Biology

Granulocyte Derived Resistin Inhibits Monocyte Maturation and Induces Immune Suppression in CMML

Nathan J. Hull, Rachel Cant, Laura A Guest, Yu‐Hung Wang, Kristian Gurashi, Roberto Paredes, Hector Huerga Encabo, Chien‐Chin Lin, Hwei‐Fang Tien, Robert Sellers, Sudhakar Sahoo, Dominique A. Bonnet, Dorothée Selimoglu‐Buet, Éric Solary, Daniel H. Wiseman, Kiran Batta

This study identifies granulocyte-derived resistin as a key factor in CMML that inhibits monocyte maturation and promotes immune suppression.

bioRxiv · Mar 3, 2025 · PreprintCancer Biology