Orthosteric and allosteric effects of anti-CRISPR II-C1 inhibition on GeoCas9 from integrated structural biophysics
Alexa L Knight, Helen B Belato, Charlotte S Dresser, Chinmai Pindi, Briana J. Mercado, Praise Lasekan, Jinping Luo, Pablo Ricardo Arantes, G. Jogl, Giulia Palermo, George P. Lisi
This study investigates how AcrIIC1 inhibits GeoCas9 by analyzing structural and dynamic changes in the HNH nuclease domain.
bioRxiv · Apr 9, 2026 · PreprintBiophysics