Optimal TELSAM-Target Protein Linker Character is TargetProtein-Dependent
Maria Jose Pedroza Romo, Alihikaua Keliiliki, Jacob C. Averett, Joseph F. Gonzalez, Ethan Noakes, Elijah W. Wilson, Conrad Smith, Blake Averett, Dalton Hansen, Riley A. Nickles, Miles Gerald Bradford, Sara Soleimani, Tobin Smith, Supeshala Nawarathnage, Prasadika Samarwickrama, , James Moody
This study evaluates linker types for enhancing crystallization of proteins fused to TELSAM, finding that linker choice depends on the target protein's properties.
bioRxiv · Aug 29, 2025 · PreprintBiochemistry