Author

Riley A. Nickles

Brigham Young UniversityORCID 0009-0009-5570-9096Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Aaron M. Wilson· 1 shared Alihikaua Keliiliki· 1 shared Ariel Kelsch· 1 shared Barry M. WillardsoniD· 1 shared Blake AverettiD· 1 shared Caelen A. Jones· 1 shared Cameron StewartiD· 1 shared Cecilia S. Sanders· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Aaron M. Wilson

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 29, 2025

Optimal TELSAM-Target Protein Linker Character is TargetProtein-Dependent

Maria Jose Pedroza Romo, Alihikaua Keliiliki, Jacob C. Averett…·James Moody

This study evaluates linker types for enhancing crystallization of proteins fused to TELSAM, finding that linker choice depends on the target protein's properties.

DOI 10.1101/2025.08.29.672704

humanprotein structure

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 28, 2025

Disease-causing mutations in the G protein β5 β-propeller disrupt its chaperonin-mediated folding trajectory

Mikaila Sass, Deirdre Mack, Riley A. Nickles…·Barry M. Willardson

This study uses cryo-EM and biochemistry to show how disease-causing mutations in Gβ5 disrupt its folding by CCT, leading to trapped intermediates and neurological disease.

2 citations

humancryo-EM

𝕏 PostBluesky