Inhibition of agr Quorum Sensing in Staphylococci by Novel Thiazole-Indole Hybrid Compounds
Weizhe Wang, Praveen Kumar Singh, Martin S. Bojer, Kirsi Savijoki, Jari T. Yli‐Kauhaluoma, Hanne Ingmer, Jayendra Z. Patel, Stephanie Fernanda Fulaz
This study identifies two thiazole-indole hybrid compounds that inhibit Staphylococcus aureus quorum sensing without affecting bacterial viability, reducing virulence factors and biofilm formation.
bioRxiv · Oct 15, 2025 · PreprintMicrobiology