Anastrozole mediated modulation of mitochondrial activity by inhibition of mitochondrial permeability transition pore opening: An initial perspective
Somesh Kumar, Neha Choudhary, Mohammed Faruq, Arun Kumar, Ravindra Kumar Saran, Prem Kumar Indercanti, Vikram Singh, Haseena Sait, Sunita Jaitley, Martin Vališ, Kamil Kuča, Sunil Kumar Polipalli, Manoj Kumar, Tejveer Singh, Prashanth Suravajhala, , Seema Kapoor
This study investigates anastrozole's effect on mitochondrial permeability transition pore (mPTP) by molecular docking, dynamics, and cell experiments, finding it more effective than cyclosporine A in inhibiting mPTP and improving mitochondrial function.
Journal of Biomolecular Structure and Dynamics · Feb 23, 2023Peer-reviewedMolecular Biology