Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial cell state
Christine Chiasson-MacKenzie, Youwen Zhang, Evan O’Loughlin, Preshita Sanjay Dave, Arul S. Menon, Vindhya Vijay, Ashley D. Westerfield, Vardhman Kumar, Sangeeta N. Bhatia, Esther Rheinbay, Nabeel M. Bardeesy, Shannon L. Stott, Andrea I. McClatchey
This study shows that different FGFR2 mutations in cholangiocarcinoma affect biliary architecture based on the epithelial state of the cells, revealing distinct phenotypic consequences.
bioRxiv · Aug 30, 2024 · PreprintCancer Biology