Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression.
Sara J. Fagen, Jeremy D. Burgess, Melina J. Lim, Danilyn Amerna, Zeynep Bengisu Kaya, Ayman H. Faroqi, Priyanka Perisetla, Natasha N. DeMeo, Iva Stojkovska, Drew J. Quiriconi, Joseph R. Mazzulli, Marion Delenclos, Suelen Lucio Boschen, Pamela J. McLean
This study shows honokiol reduces alpha-synuclein mRNA and protein levels in models of Parkinson's disease by modulating SNCA gene expression, identifying potential therapeutic targets.
Frontiers in Aging Neuroscience · Aug 10, 2023Peer-reviewedNeuroscience