Jeremy D. Burgess

One hour of 200 mM sorbitol collapses most chromatin loops in human cells while several hundred transient, cohesin-dependent, CTCF-independent loops form at active promoters, preceding anchor-gene activation.

This study uses single-cell RNA sequencing to analyze how fibronectin fragment treatment alters chondrocyte states and transcriptional programs in primary human cells.

This study shows honokiol reduces alpha-synuclein mRNA and protein levels in models of Parkinson's disease by modulating SNCA gene expression, identifying potential therapeutic targets.

This study shows that alpha-synuclein oligomers reduce mitochondrial SIRT3 activity, impair mitochondrial dynamics, and that AICAR treatment restores SIRT3 and improves mitochondrial dysfunction in Parkinson's disease models.