Author

Joseph R. Mazzulli

Northwestern UniversityORCID 0000-0002-7692-2381Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Addison M. DudaiD· 1 shared Adriana FerreiraiD· 1 shared Alberto BartesaghiiD· 1 shared Alexis D. RickmaniD· 1 shared Amira AffanehiD· 1 shared Andrea E. MurmanniD· 1 shared Andrew B. WestiD· 1 shared Arpine SokratianiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperNeuroscience

Addison M. DudaORCID

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3 papers

Recent·Most cited

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases

Arpine Sokratian, Ye Zhou, Meltem Tatlı, Kevin J. Burbidge, Enquan Xu, Elizabeth G. Viverette, Sonia Donzelli, Addison M. Duda, Yuan Yuan, Huizhong Li, Samuel Strader, Nirali Patel, Lauren Shiell, Tuyana B. Malankhanova, Olivia Chen, , Andrew B. West

This study reports the atomic structure of mouse α-synuclein fibrils and shows they differ structurally and functionally from human fibrils linked to Parkinson's and MSA.

Science Advances · Nov 1, 2024Peer-reviewedNeuroscience

Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression.

Sara J. Fagen, Jeremy D. Burgess, Melina J. Lim, Danilyn Amerna, Zeynep Bengisu Kaya, Ayman H. Faroqi, Priyanka Perisetla, Natasha N. DeMeo, Iva Stojkovska, Drew J. Quiriconi, Joseph R. Mazzulli, Marion Delenclos, Suelen Lucio Boschen, Pamela J. McLean

This study shows honokiol reduces alpha-synuclein mRNA and protein levels in models of Parkinson's disease by modulating SNCA gene expression, identifying potential therapeutic targets.

Frontiers in Aging Neuroscience · Aug 10, 2023Peer-reviewedNeuroscience

Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer's disease and aging

Bidur Paudel, Si‐Yeon Jeong, Carolina Peña-Martinez, Alexis D. Rickman, Ashley Haluck-Kangas, Elizabeth T. Bartom, Kristina Fredriksen, Amira Affaneh, John A. Kessler, Joseph R. Mazzulli, Andrea E. Murmann, Emily Joy Rogalski, Changiz Geula, Adriana Ferreira, Bradlee L. Heckmann, , Marcus E. Peter

The paper identifies DISE, an RNA interference-mediated cell death mechanism, as correlated with neurotoxicity in Alzheimer's disease and aging, showing shifts in 6mer seed toxicity in different models.

bioRxiv · Sep 8, 2022 · PreprintNeuroscience