Beyond the skin barrier: commensal S. epidermidis imprint systemic immunity to invasive biofilm infection
Pia Fehrenbach, Elian M.A. Kuhn, Lena Gens, James Tapia-Dean, Javier Rangel‐Moreno, Alisa Hangartner, Puk Kwant, Stephan Zeiter, Esther C. de Jong, Gowrishankar Muthukrishnan, T. Fintan Moriarty
This study shows that early life exposure to S. epidermidis shapes immune responses to invasive biofilm infections later in life, with neonatal colonization leading to distinct immune modulations compared to adult colonization.
bioRxiv · Apr 30, 2026 · PreprintImmunology